Cytosolic Protein Delivery: Programed Assembly of Nucleoprotein Nanoparticles Using DNA and Zinc Fingers for Targeted Protein Delivery (Small 52/2018)
Source abstract
Abstract
In article number 1802618, Joong-jae Lee, Hak-Sung Kim, and co-workers develop an intracellular protein delivery system by sequence specific DNA-protein interactions for targeted therapy. Engineered nucleoproteins are sequentially assembled onto the surface of gold nanoparticles. The resulting nucleoprotein nanoparticles exhibit highly programmable designability for functional protein loading, and remarkable growth retardation of tumor cells with a negligible toxic effect.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: RNA Interference and Gene Delivery · Advanced biosensing and bioanalysis techniques
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Affiliations
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 South Korea
Advanced Radiation Technology Institute Korea Atomic Energy Research Institute (KAERI) Jeongup 56212 South Korea
Division of Bio‐Imaging Korea Basic Science Institute (KBSI) Chuncheon 24341 South Korea
Department of Biochemistry Kangwon National University Chuncheon 24341 South Korea
Institute of Life Sciences (ILS) Kangwon National University Chuncheon 24341 South Korea
References
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