DataVXSmallPaper
journal article·2017-01Open access

Pancreatic Cancer: Targeted Co‐delivery of PTX and TR3 siRNA by PTP Peptide Modified Dendrimer for the Treatment of Pancreatic Cancer (Small 2/2017)

Yang Li, Hebin Wang, Kai Wang, Qinglian Hu, Qi Yao, Youqing Shen, Guocan Yu, Guping Tang

Small· Volume 13· Issue 2
Publisher pageOpen full text
Source abstract

Abstract

A new type of tumor-targeted nanovehicle (PSPGP) is successfully synthesized for co-delivery of PTX (paclitaxel) and TR3 siRNA, by G. Yu, G. Tang, and co-workers in article number 1602697. In vitro and in vivo investigations demonstrate that the redox-responsive PSPGP exhibited enhanced endosomal escape and intracellular degradation, which facilitates PTX and TR3 siRNA release, effectively improving the anti-tumor efficacy.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: RNA Interference and Gene Delivery · Nanoplatforms for cancer theranostics · Dendrimers and Hyperbranched Polymers

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Chemical Biology and Pharmaceutical Chemistry Department of Chemistry Zhejiang University Hangzhou 310028 China

College of Life Sciences Tarim University Alar 843300 China

College of Biotechnology and Bioengineering Zhejiang University of Technology Hangzhou 310032 China

Center for Bionanoengineering and State Key Laboratory for Chemical Engineering Department of Chemical and Biological Engineering Zhejiang University Hangzhou 310027 China

Laboratory of Molecular Imaging and Nanomedicine (LOMIN) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health (NIH) Bethesda MD 20892 USA

References

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