Microfluidic Chips: An Early‐Stage Atherosclerosis Research Model Based on Microfluidics (Small 15/2016)
Source abstract
Abstract
On page 2022, a microfluidic atherosclerosis (AS) model reconstituting early-stage AS is designed by X. Jiang and co-workers. Physiological or AS-prone hemodynamic conditions are recapitulated on the model. Under a hemodynamic background, AS-prone biochemical factors such as hyperglycemia, hyperlipidemia, angiotensin-II, tumor necrosis factor-α (TNF-α) and lipopolysaccharides lead to dysfunction of the endothelial cells. The on-chip model recaptures the atherogenic responses of endothelial cells in ways that a Petri dish cannot. Platinum nanoparticles (Pt-NPs) can treat AS-prone pathology on the model, which is in good agreement with the results on mouse.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Single-cell and spatial transcriptomics · 3D Printing in Biomedical Research
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Affiliations
Beijing Engineering Research Center for BioNanotechnology CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for NanoScience and Technology No.11 BeiYiTiao, ZhongGuanCun Beijing 100190 P. R. China
College of Physics and Collaborative Innovation Center for Marine Biomass Fibers Materials and Textiles of Shandong Province Qingdao University No. 308 Ningxia Road Qingdao 266071 China
References
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