Gene Delivery: Single‐Layered MoS₂–PEI–PEG Nanocomposite‐Mediated Gene Delivery Controlled by Photo and Redox Stimuli (Small 9/2016)

A spatiotemporally controllable gene delivery carrier is developed using a polymer-conjugated, single layered MoS2 nanocomposite by W. J. Kim and co-workers on page 1184. When subjected to near infrared light, the photothermal effect of MoS2 induces the endosomal escape of nanocomposite, thereby transferring it into the cytosol. Subsequently, intracellular redox conditions release the polymers from MoS2, facilitating the gene release from the nanocomposite. The sequential process responds to external and internal stimuli, maximizing the delivery efficiency of its gene contents.