Nano-immunoengineering: Nanoparticle-Based Manipulation of Antigen-Presenting Cells for Cancer Immunotherapy (Small 41/2015)

On page 5483, L. Zhang and co-workers describe the process of nanoparticle-mediated antigen presentation. A dendritic cell takes up cell membrane-coated nanoparticles that are loaded with an immunological adjuvant. After uptake, the tumor antigens on the nanoparticle-stabilized membrane are processed and presented on the surface of the dendritic cell. Meanwhile, the adjuvant is released and causes the dendritic cell to mature, ultimately enabling it to activate tumor antigen-specific T cells (shown here as green).