Biosensors: On‐line SERS Detection of Single Bacterium Using Novel SERS Nanoprobes and A Microfluidic Dielectrophoresis Device (Small 22/2014)
Source abstract
Abstract
On-line multiplex SERS detection of pathogenic bacteria is demonstrated at a single-cell level. On page 4700, L.-K. Chau, C.-Y. Yang, and co-workers prepare SERS nanoprobes via immobilization of antibodies on silica-coated, dye-induced aggregate beads of gold nanoparticles (AuNPs). The beads give an enhanced Raman signal due to well-defined plasmonic hot spots at junctions between AuNPs. In combination with dielectrophoresis, they improve the sensitivity of SERS-barcode biosensing strategies beyond that of whole-cell ELISA. The practical detection limit over 10 min is 70 CFU mL−1.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Biosensors and Analytical Detection · Bacteriophages and microbial interactions
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Affiliations
Department of Chemistry and Biochemistry and Center for Nano Bio‐Detection (AIM‐HI) National Chung Cheng University Chiayi 62102 Taiwan
Department of Mechanical Engineering National Chung Cheng University Chiayi 62102 Taiwan
Institute of Molecular Biology National Chung Hsing University Taichung 40227 Taiwan
References
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