Metallofullerenols: Polyhydroxylated Metallofullerenols Stimulate IL‐1β Secretion of Macrophage through TLRs/MyD88/NF‐κB Pathway and NLRP3 Inflammasome Activation (Small 12/2014)
Source abstract
Abstract
Metallofullerenols uptaken by macrophages can promote the production of inflammatory cytokines like IL-1β by triggering two signaling pathways indepentently. As reported on page 2362 by C. Chen and co-workers, fullerenols prime macrophages to express pro-IL-1β viaTLRs/MyD88 pathway and subsequently activate NF-κB. Importantly, they activate NLRP3 inflammasome in macrophages, which is required for processing pro-IL-1β into mature IL-1β. These findings contibute to better understanding their underlying mechanism of antitumor chemotherapeutics and good immunoregulatory effects.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Inflammasome and immune disorders
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Science Beijing 100190 China
Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Science Shanghai 201204 China
References
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