Cancer Therapy: Single‐Cell‐Level Microplasma Cancer Therapy (Small 16/2011)

The image shows the apoptotic response in B16F0 tumor cells induced by a 15 μm hollow-core optical fiber microplasma jet assay using the TUNEL assay, which detects DNA nicks–an important cell apoptotic indicator. Apoptotic tumor cells treated by the plasma device show DNA nicks, and their nuclei are dyed to a bright color by the imaging assay kit, whereas no response was found in untreated cells. A well-defined boundary between plasma-treated and nontreated areas can be observed. This work enables new directed cancer therapies based on a highly flexible and precise hollow, optical-fiber-based microplasma cancer endoscope, and it offers unique advantages to understanding plasmainduced tumor cell apoptosis.