Immunoengineering: Biodegradable Nanoellipsoidal Artificial Antigen Presenting Cells for Antigen Specific T‐Cell Activation (Small 13/2015)

Nonspherical ellipsoidal nanodimensional artificial antigen-presenting cells (aAPCs) are fabricated by J. J. Green and co-workers and on page 1519 they are shown to have superior T-Cell activation and pharmacokinetic properties compared to equivalent spherical nanodimensional aAPCs. Shown on the cover are transmission electron microscopy images of the ellipsoidal nanoparticles interacting with a computer generated T-Cell membrane as nano aAPCs. Due to their larger radius of curvature, ellipsoidal nano aAPCs are more effective at biomimicry of natural APCs for antigen-specific T-Cell activation.