DataVXSmallPaper
journal article·2021-04

Liver‐on‐a‐Chip: Bioengineered Multicellular Liver Microtissues for Modeling Advanced Hepatic Fibrosis Driven Through Non‐Alcoholic Fatty Liver Disease (Small 14/2021)

Hyun‐Jong Cho, Han‐Jun Kim, KangJu Lee, Soufian Lasli, Aly Ung, Tyler Hoffman, Rohollah Nasiri, Praveen Bandaru, Samad Ahadian, Mehmet R. Dokmeci, Junmin Lee, Ali Khademhosseini

Small· Volume 17· Issue 14
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Source abstract

Abstract

In article number 2007425, Junmin Lee, Ali Khademhosseini, and co-workers present a breakthrough for modeling of non-alcoholic fatty liver disease (NAFLD) based on bioengineered multicellular liver microtissues and a liver-on-a-chip system. The microtissues consisting of four major liver cell types (primary human hepatocytes, stellate cells, Kupffer cells, and endothelial cells) recapitulate the pathogenesis of hepatic fibrosis driven by NAFLD.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: 3D Printing in Biomedical Research

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Affiliations

Department of Bioengineering Henry Samueli School of Engineering and Applied Sciences University of California‐Los Angeles Los Angeles CA 90095 USA

Center for Minimally Invasive Therapeutics (C‐MIT) University of California‐Los Angeles Los Angeles CA 90095 USA

College of Pharmacy Kangwon National University Chuncheon Gangwon 24341 Republic of Korea

Terasaki Institute for Biomedical Innovation Los Angeles CA 90064 USA

Department of Healthcare Medical Engineering Chonnam National University Yeosu 59626 Republic of Korea

Department of Radiological Sciences David Geffen School of Medicine University of California‐Los Angeles Los Angeles CA 90095 USA

Department of Chemical and Biomolecular Engineering Henry Samueli School of Engineering and Applied Sciences University of California‐Los Angeles Los Angeles CA 90095 USA

References

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