DataVXSmallPaper
journal article·2018-03Open access

Influenza Nanovaccines: Intranasal Nanovaccine Confers Homo‐ and Hetero‐Subtypic Influenza Protection (Small 13/2018)

Mi Qi, Xian‐En Zhang, Xianxun Sun, Xiaowei Zhang, Yanfeng Yao, Siling Liu, Ze Chen, Wei Li, Zhiping Zhang, Jianjun Chen, Zongqiang Cui

Small· Volume 14· Issue 13
Publisher pageOpen full text
Source abstract

Abstract

In article number 1703207, Jianjun Chen, Zongqiang Cui, and co-workers develop an intranasal nanovaccine which provides protection against homo- and heterosubtypic influenza. The 3M 2e-rHF nanovaccine is constructed by displaying three-sequential repeats of the influenza conserved antigen M2e on the self-assembling recombinant human heavy chain ferritin (rHF) cage. Intranasal vaccination with 3M2e-rHF in the absence of adjuvants confers complete protection against a lethal infection of homosubtypic H1N1 and heterosubtypic H9N2 virus.
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Research context

Nanomaterials

OpenAlex topics: Influenza Virus Research Studies · interferon and immune responses · Respiratory viral infections research

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Affiliations

State Key Laboratory of Virology Wuhan Institute of Virology University of Chinese Academy of Sciences Wuhan 430071 China

Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China

Institute of Animal Husbandry and Veterinary Science Wuhan Academy of Agricultural Science and Technology Wuhan 430208 China

Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China

College of Life Sciences Hunan Normal University Changsha 410013 China

References

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