DataVXSmallPaper
journal article·2017-04Open access

Organ‐On‐A‐Chip: Biomechanical Strain Exacerbates Inflammation on a Progeria‐on‐a‐Chip Model (Small 15/2017)

João Ribas, Yu Shrike Zhang, Patrícia R. Pitrez, Jeroen Leijten, Mario Miscuglio, Jeroen Rouwkema, Mehmet Remzi Dokmeci, Xavier Nissan, Lino Ferreira, Ali Khademhosseini

Small· Volume 13· Issue 15
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Source abstract

Abstract

A progeria-on-a-chip is developed to recapitulate the biomechanical dynamics of vascular disease and aging, shown in article number 1603737, by Lino Ferreira, Ali Khademhosseini, and co-workers. The model stretches vascular smooth muscle cells and shows an exacerbated inflammation and DNA damage. The progeria-on-a-chip is expected to drive the discovery of new drugs and to elucidate the role of strain in vascular aging and disease.
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Research context

OpenAlex topics: 3D Printing in Biomedical Research

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Affiliations

Biomaterials Innovation Research Center Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge MA 02139 USA

Harvard‐MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge MA 02139 USA

Doctoral Program in Experimental Biology and Biomedicine Center for Neuroscience and Cell Biology Institute for Interdisciplinary Research University of Coimbra 3030‐789 Coimbra Portugal

CNC‐Centre for Neuroscience and Cell Biology University of Coimbra 3030‐789 Coimbra Portugal

Institute for Interdisciplinary Research University of Coimbra 3030‐789 Coimbra Portugal

Department of Developmental BioEngineering MIRA Institute for Biomedical Technology and Technical Medicine University of Twente 7500 AE Enschede The Netherlands

Department of Biomechanical Engineering MIRA Institute for Biomedical Technology and Technical Medicine University of Twente 7500 AE Enschede The Netherlands

CECS, INSERM U861 I‐STEM AFM Institute for Stem Cell Therapy and Exploration of Monogenic Diseases 28 Rue Henri Desbrueres 91100 Corbeil‐Essones France

Department of Physics King Abdulaziz University Jeddah 21569 Saudi Arabia

Department of Bioindustrial Technologies College of Animal Bioscience and Technology Konkuk University Hwayang‐dong Gwangjin‐gu Seoul 143‐701 Republic of Korea

References

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