Mesoporous Nanoparticles: Facile Synthesis of Yolk-Shell-Structured Triple-Hybridized Periodic Mesoporous Organosilica Nanoparticles for Biomedicine (Small 26/2016)

On page 3550, G. Lu, L. Wang, and co-workers report yolk–shell structured periodic mesoporous organosilica (PMO) nanoparticles simultaneously incorporated with ethane, thioether, and benzene moieties. The unique yolk–shell structure is formed via hydrothermal treatment of triple-hybridized PMOs synthesized using a surfactant-directed sol–gel process. Excellent biobehaviors, bioimaging properties, and high anticancer drug loading capacity endowed by the triple-hybridized groups are demonstrated.