DataVXSmallPaper
journal article·2016-03Open access

Micelles: Rod‐to‐Globule Transition of pDNA/PEG–Poly(l‐Lysine) Polyplex Micelles Induced by a Collapsed Balance Between DNA Rigidity and PEG Crowdedness (Small 9/2016)

Theofilus A. Tockary, Kensuke Osada, Yusuke Motoda, Shigehiro Hiki, Qixian Chen, Kaori M. Takeda, Anjaneyulu Dirisala, Shigehito Osawa, Kazunori Kataoka

Small· Volume 12· Issue 9
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Source abstract

Abstract

Upon PEG removal, the change of rod shapes into globule shapes is observed for packaged DNA in polyplex micelles that are prepared from block copolymers with acid-labile linkage between the PEG and poly(L-lysine) (PLys). On page 1193, K. Osada, K. Kataoka, and co-workers use the details of this transition behavior to elucidate the essential regulating factors of polyplex micelle structures, in order to find their structure–function relationship and promote their utilization as a gene delivery system.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: DNA and Nucleic Acid Chemistry · RNA Interference and Gene Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Materials Engineering Graduate School of Engineering The University of Tokyo 7‐3‐1 Hongo Bunkyoku, Tokyo 113‐8656 Japan

Department of Bioengineering Graduate School of Engineering The University of Tokyo 7‐3‐1 Hongo Bunkyoku, Tokyo 113‐8656 Japan

Japan Science and Technology Agency PRESTO 4‐1‐8 Honcho Kawaguchi, Saitama 332‐0012 Japan

Division of Clinical Biotechnology Center for Disease Biology and Integrative Medicine Graduate School of Medicine The University of Tokyo 7‐3‐1 Hongo Bunkyoku, Tokyo 113‐8656 Japan

References

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