Peptoids: Antiamyloidogenic Activity of Aβ42-Binding Peptoid in Modulating Amyloid Oligomerization (Small 1/2017)

Antiamyloidogenic agents have promising application potential in AD therapies. In article number 1602857, L. Zhu, Z. Hu, Y. Yang, and co-workers present an Aβ42-binding agent amyloid inhibitory 1 (AIP1), demonstrate its inhibitory effect on Aβ42 oligomerization and fibrillation, and show that AIP1 rescue Aβ42-induced cytotoxicity through decreasing Aβ42 oligomer content is related to cell membrane permeability.