DataVXSmallPaper
journal article·2016-07Open access

siRNA Delivery: Mastering Dendrimer Self‐Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing (Small 27/2016)

Chao Chen, Paola Posocco, Xiaoxuan Liu, Qiang Cheng, Erik Laurini, Jiehua Zhou, Cheng Liu, Yang Wang, Jingjie Tang, Valentina Dal Col, Tianzhu Yu, Suzanne Giorgio, Maurizio Fermeglia, Fanqi Qu, Zicai Liang, John J. Rossi, Minghua Liu, Palma Rocchi, Sabrina Pricl, Ling Peng

Small· Volume 12· Issue 27
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Source abstract

Abstract

Supramolecular dendrimers created from small amphiphilic dendrons are able to mimic covalently constructed high-generation dendrimers for siRNA delivery, as presented by S. Pricl, L. Peng, and co-workers on page 3667. An optimal balance between the hydrophobic alkyl chain length and the hydrophilic dendritic portion is crucial for self-assembly of these amphiphilic dendrons into micellar nanostructures, and critically impacts the effectiveness of siRNA delivery and functional gene silencing.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: RNA Interference and Gene Delivery · Dendrimers and Hyperbranched Polymers · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Aix‐Marseille Université CNRS Centre Interdisciplinaire de Nanoscience de Marseille UMR 7325 Equipe Labellisée Ligue Contre le Cancer 13288 Marseille France

Aix‐Marseille Université CNRS Institut de Chimie Radicalaire, UMR 7273 13390 Marseille France

College of Chemistry and Molecular Sciences Wuhan University Wuhan 430072 P. R. China

Molecular Simulation Engineering (MOSE) Laboratory Department of Engineering and Architecture (DEA) University of Trieste Piazzale Europa 1 34127 Trieste Italy

National Interuniversity Consortium for Material Science and Technology (INSTM) Research Unit MOSE‐DEA University of Trieste Trieste 34127 Italy

Centre de Recherche en Cancérologie de Marseille Inserm, UMR 1068 CNRS UMR 7258, Aix Marseille Université U105 Institut Paoli Calmettes 13009 Marseille France

Laboratory of Nucleic Acid Technology Institute of Molecular Medicine Peking University 100871 Beijing China

Department of Molecular and Cellular Biology Beckman Research Institute CA 91010 USA

Irell and Manella Graduate School of Biological Sciences Beckman Research Institute CA 91010 USA

Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Colloids and Surfaces Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

References

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