Synthesis of Lipophilic Quinazolinone Template as Pollutant's Scavenger in Aqueous System and Evaluation of Its Anti‐Yeast Activity

Abstract Non‐polymeric small amphiphiles have attained a significant role in various applications due to their defined and consistent molecular assembly and hydrophobic/lipophilic balance. Synthesized Amphiphiles 2‐(5‐(bis(dodecylthio)methyl)‐2‐hydroxyphenyl)quinazolin‐4(3H)‐one (Q‐C12) has been recognized as new amphiphiles. The structurally Q‐C12 has a fluorescent quinazolinone moiety attached with two sulfur centers and two long alkyl chains. The structural uniqueness of Q‐C12 for the presence of sulfur‐based alkyl chain backbone makes it selective towards the detection of mercury (Hg²⁺) ions, followed by the scavenging from the aqueous system. It also shows its ability to detect and bind with diethyl chlorophosphate (DCP), a toxic stimulant for nerve agents, using its fluorescence efficacy. Each observation has been well studied using NMR, fluorescence, and DLS analysis. Further, Q‐C12 behaves very effectively as an anti‐yeast agent. The yeast cell imaging study has been captured against yeast Pichia sp. strain KG2 using Fluorescent Q‐C12. The development of low‐cost and functional amphiphile, Q‐C12 claims great promise for environmental monitoring, advanced material, and biomedical innovations, and also offers a multifunctional approach to addressing key challenges in pollution control and healthcare.