Quantitative, Label‐Free Mapping of Cell Force Dynamics
Source abstract
Abstract
Abstract Label‐free plasmonic cell force microscopy is developed to reveal cell exerted force at diffraction‐limited spatial resolution. By quantifying cell‐substrate interaction dynamics in real‐time through plasmonic scattering imaging, the spatial and temporal evolutions of cellular forces are accurately mapped. To demonstrate the capability of the technology, cardiomyocyte force evolution and loading rates are measured with millisecond resolution. Furthermore, cell force responses to nicotinic receptor activation are monitored and observed heterogenic cell force changes among a population of cells, underscoring the versatility and potential impact of this label‐free approach.
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Research context
OpenAlex topics: Cellular Mechanics and Interactions · Force Microscopy Techniques and Applications · Microfluidic and Bio-sensing Technologies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Biodesign Center for Bioelectronics and Biosensors Arizona State University Tempe AZ 85287 USA
School of Biological and Health Systems Engineering Arizona State University Tempe AZ 85287 USA
School of Electrical Energy and Computer Engineering Arizona State University Tempe AZ 85287 USA
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