DataVXSmallPaper
journal article·2024-10Open access

Tailored Polymersomes for Enhanced Oral Drug Delivery: pH‐Sensitive Systems for Intestinal Delivery of Immunosuppressants (Small 43/2024)

Matteo Tollemeto, Sintija Ursulska, Pascal L. W. Welzen, Lasse H. E. Thamdrup, Atena Malakpour‐Permlid, Yudong Li, Gohar Soufi, Tania Patiño Padial, Jørn B. Christensen, Line Hagner Nielsen, Jan van Hest, Anja Boisen

Small· Volume 20· Issue 43
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Source abstract

Abstract

Oral Drug Delivery In article number 2403640, Matteo Tollemeto and co-workers aimed to design a nanoparticle drug delivery system that maintains drug solubility while delaying absorption from the stomach to the intestine. In vivo rat studies of pH-responsive polymersomes showed reduced stomach absorption and enhanced intestinal absorption, offering a promising treatment for inflammatory bowel disease.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: Advanced Drug Delivery Systems · Nanoparticle-Based Drug Delivery · RNA Interference and Gene Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The Danish National Research Foundation and Villum Foundation's Center IDUN Department of Health Technology Technical University of Denmark Kongens Lyngby 2800 Denmark

Department of Biomedical Engineering Institute for Complex Molecular Systems Eindhoven University of Technology Eindhoven 5600 MB The Netherlands

Department of Chemistry University of Copenhagen Thovaldsensvej 40 Frederiksberg DK‐1871 Denmark

References

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