DataVXSmallPaper
journal article·2023-12Open access

Unveiling the Influence of Tumor Microenvironment and Spatial Heterogeneity on Temozolomide Resistance in Glioblastoma Using an Advanced Human In Vitro Model of the Blood‐Brain Barrier and Glioblastoma (Small 52/2023)

Maxine SY Lam, Joey JY Aw, Damien Tan, Ragavi Vijayakumar, Hui Yi Grace Lim, Swathi Yada, Qing You Pang, Nick Barker, Carol Tang, Beng Ti Ang, Radoslaw M. Sobota, Andrea Pavesi

Small· Volume 19· Issue 52
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Source abstract

Abstract

Microfluidic Models In article number 2302280, Andrea Pavesi and co-workers develop an in vitro 3D glioblastoma model, that incorporates a perfusable blood-brain barrier. The model recapitulates key features of clinical disease, such as a diffusive infiltrating tumor front and tumor-associated dysregulation of vascular permeability. The authors further demonstrate the compatibility with next-generation ultra-sensitive mass spectrometry to explore proteins involved in tumorigenesis and drug resistance.
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Research context

OpenAlex topics: Mathematical Biology Tumor Growth

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Affiliations

Institute of Molecular and Cell Biology Agency for Science Technology and Research (A*STAR) 61 Biopolis Drive Singapore 138673 Singapore

Functional Proteomics Laboratory SingMass National Laboratory Institute of Molecular and Cell Biology Agency for Science Technology and Research (A∗STAR) 61 Biopolis Drive Singapore 138673 Singapore

Neuro‐Oncology Research Laboratory Department of Research National Neuroscience Institute Singapore 308433 Singapore

Duke‐National University of Singapore Medical School Singapore 169857 Singapore

School of Biological Sciences Nanyang Technological University Singapore 637551 Singapore

Department of Neurosurgery National Neuroscience Institute Singapore 308433 Singapore

Mechanobiology Institute National University of Singapore Singapore 117411 Singapore

References

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