Synergistic Lysosomal Impairment and ER Stress Activation for Boosted Autophagy Dysfunction Based on Te Double‐Headed Nano‐Bullets (Small 27/2022)

Autophagy To overcome the autophagy compromised mechanism of protective cellular processes by “eating” damaged organelles or potentially toxic materials in tumor cells, Nan Li and co-workers show how tellurium double-headed nanobullets (TeDNBs)-HO is utilized to induce autophagy dysfunction. On the one hand, TeDNBs-mediated endoplasmic reticulum stress could excessively induce autophagy; thus, resulting in autophagosome accumulation. On the other hand, omeprazole would deacidify and impair lysosomes, therefore blocking autophagosome degradation. More details can be found in article number 2201585.