DataVXSmallPaper
journal article·2023-11Open access

Photonic‐Plasmonic Coupling Enhanced Fluorescence Enabling Digital‐Resolution Ultrasensitive Protein Detection (Small 44/2023)

Priyash Barya, Yanyu Xiong, Skye Shepherd, Rohit Gupta, Lucas D. Akin, Joseph Tibbs, Hankeun Lee, Srikanth Singamaneni, Brian T. Cunningham

Small· Volume 19· Issue 44
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Source abstract

Abstract

Digital-Resolution Ultrasensitive Protein Detection The synergistic coupling between a plasmonic nanostructure and a photonic crystal resonator enables a 52-fold improvement in the emission intensity of fluorescent dye molecules due to strong near-field enhancement, improved extraction efficiency, and an increased rate of spontaneous emission. This substantial boost in signal-to-noise ratio allows for the imaging and digital counting of human interleukin-6 with a 10 fg mL−1 limit of detection and a 7-log dynamic range. More details can be found in article number 2207239 by Srikanth Singamaneni, Brian T. Cunningham, and co-workers.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Advanced Biosensing Techniques and Applications · Advanced biosensing and bioanalysis techniques · Photodynamic Therapy Research Studies

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Affiliations

Department of Electrical and Computer Engineering University of Illinois at Urbana−Champaign Urbana IL 61801 USA

Holonyak Micro and Nanotechnology Laboratory University of Illinois at Urbana−Champaign Urbana IL 61801 USA

Carl R. Woese Institute for Genomic Biology University of Illinois at Urbana−Champaign Urbana IL 61801 USA

Department of Bioengineering University of Illinois at Urbana‐Champaign Urbana IL 61801 USA

Department of Mechanical Engineering and Materials Science Institute of Materials Science and Engineering Washington University in St. Louis St. Louis MO 63130 USA

Department of Chemistry University of Illinois at Urbana‐Champaign Urbana IL 61801 USA

References

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