Controllable Fabrication of Highly Uniform Sub‐10 nm Nanoparticles from Spontaneous Confined Nanoemulsification (Small 34/2023)

Polymeric Nanoparticles In article number 2300801, Liang-Yin Chu, Wei Wang, and co-workers develop a spontaneous confined nanoemulsification strategy to facilely fabricate sub-10 nm uniform polymeric nanoparticles by template synthesis of nanoemulsions. The strategy employs a self-confined reaction with highly accumulated surfactants in chemically-active droplets to achieve enhanced molecular-level interfacial instability for creating sub-10 nm nanodroplets, and allows controllable fabrication of uniform sub-10 nm polymeric nanoparticles with efficient drug encapsulation in continuous, scalable and low-energy manner.