DataVXSmallPaper
journal article·2022-09

Toxin‐Enabled “On‐Demand” Liposomes for Enhanced Phototherapy to Treat and Protect against Methicillin‐Resistant Staphylococcus aureus Infection (Small 35/2022)

Deli Zhuge, Mengchun Chen, Xuewei Yang, Xufei Zhang, Lulu Yao, Li Li, Haonan Wang, Hao Chen, Qingqing Yin, Dongyan Tian, Cuiye Weng, Shuangshuang Liu, Pengpeng Xue, Yijing Lin, Yiruo Sun, Zhuoying Huang, Cen Jie‐Nuo Ye, Lan Shen, Joo Young Huh, Weiliang Xia, Yingzheng Zhao, Yijie Chen

Small· Volume 18· Issue 35
Publisher page
Source abstract

Abstract

MRSA Phototherapy In article number 2203292, Weiliang Xia, Yingzheng Zhao, Yijie Chen, and co-workers show that Van-Lipo(IR780)-PFC (an oxygen-carrying perfluorocarbon nanoemulsion stabilized by a vancomycin-functionalized sphingo-myelin liposome loaded with IR780) can capture methicillin-resistant Staphylococcus aureus (MRSA) toxins in situ, resulting in the on-demand release of phototherapeutic agents, thus improving the specificity of photothermal therapy/photodynamic therapy under near-infrared irradiation. Meanwhile, pore formation upon the insertion of toxins into the nanoparticles results in the generation of vaccines in situ, thus leading to an anti-MRSA immune response.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Cancer Research and Treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Obstetrics and Gynecology the Second Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang 325027 China

Department of Pharmaceutics School of Pharmaceutical Sciences of Wenzhou Medical University Wenzhou Zhejiang 325035 China

Chonnam National University College of Pharmacy Gwangju 61186 Republic of Korea

Wenzhou Medical University Wenzhou Zhejiang 325035 China

State Key Laboratory of Oncogenes and Related Genes Ren Ji Hospital School of Medicine and School of Biomedical Engineering Shanghai Jiao Tong University Shanghai 200030 China

References

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