DataVXSmallPaper
journal article·2021-06

Diagnosis of Autoimmune Diseases: Nanocage‐Based Capture‐Detection System for the Clinical Diagnosis of Autoimmune Disease (Small 25/2021)

Yanan Zhang, Yingni Li, Jianlin Zhang, Xuehui Chen, Ruofei Zhang, Guoming Sun, Bing Jiang, Kelong Fan, Zhanguo Li, Xiyun Yan

Small· Volume 17· Issue 25
Publisher page
Source abstract

Abstract

In article number 2101655, Kelong Fan, Zhanguo Li, Xiyun Yan, and co-workers develop a highly sensitive platform for diagnosis of autoimmune disease. The antigen and anti-Fc peptides are displayed on the surface of ferritin to construct nanocage-based capture-detection system. Multimeric display significantly enhances their binding ability to corresponding antibodies, thus improving the detection sensitivity 100–1000-folds higher than that of conventional ELISA methods.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Advanced Biosensing Techniques and Applications · Biosensors and Analytical Detection · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide Pharmaceutical Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China

University of Chinese Academy of Sciences Beijing 100049 China

Department of Rheumatology and Immunology Peking University People's Hospital and Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135) Beijing 100044 China

Experimental Center of Advanced Materials School of Materials Science and Engineering Beijing Institute of Technology Beijing 100081 China

Nanjing Nanozyme Tech Co., Ltd. Nanjing 211500 China

Nanozyme Medical Center School of Basic Medical Sciences Zhengzhou University Zhengzhou 450052 China

State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Beijing 100871 China

Peking‐Tsinghua Center for Life Sciences Peking University Beijing 100871 China

References

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