DataVXSmallPaper
journal article·2019-04Open access

High‐Throughput Drug Screening: A Microfabricated Sandwiching Assay for Nanoliter and High‐Throughput Biomarker Screening (Small 15/2019)

Praveen Bandaru, Dafeng Chu, Wujin Sun, Soufian Lasli, Chuanzhen Zhao, Shuang Hou, Shiming Zhang, Jiahua Ni, Giorgia Cefaloni, Samad Ahadian, Mehmet Remzi Dokmeci, Shiladitya Sengupta, Junmin Lee, Ali Khademhosseini

Small· Volume 15· Issue 15
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Source abstract

Abstract

In article number 1900300, Junmin Lee, Ali Khademhosseini, and co-workers develop a nanoliter and high-throughput drug screening platform based on the combination of microwell arrays as a cell culture substrate, and micropillar arrays for drug delivery and biomolecular detection in response to drugs. The developed platform requires only a small amount of sample volume from a few cells and demonstrates increasing control and throughput while allowing direct and real-time on-chip measurements. It is expected to aid in improving drug screening on patient biopsies from solid tumors to realize personalized cancer therapy.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: 3D Printing in Biomedical Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Bioengineering Henry Samueli School of Engineering and Applied Sciences University of California‐Los Angeles Los Angeles CA 90095 USA

Center for Minimally Invasive Therapeutics (C‐MIT) University of California‐Los Angeles Los Angeles CA 90095 USA

Department of Chemistry and Biochemistry University of California‐Los Angeles Los Angeles CA 90095 USA

Department of Molecular and Medical Pharmacology University of California‐Los Angeles Los Angeles CA 90095 USA

Department of Radiology David Geffen School of Medicine University of California‐Los Angeles Los Angeles CA 90095 USA

Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School Cambridge MA 02139 USA

Harvard‐MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge MA 02139 USA

Department of Chemical and Biomolecular Engineering Henry Samueli School of Engineering and Applied Sciences University of California‐Los Angeles Los Angeles CA 90095 USA

References

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