Metallothioneins Initiate Semiconducting Nanoparticle Cellular Toxicity
Source abstract
Abstract
The toxicity of CdSe nanoparticles is mediated by metallothioneins (MTs), which are ubiquitous and cysteine-rich. Surface Cd2+ ions are depleted from thiocarboxylate-capped CdSe nanoparticles by recombinant MT-based peptides (see figure), while surface Zn2+ ion depletion from ZnS-coated CdSe nanoparticles is more difficult. Due to the overall cellular expression and antioxidant roles for MT, a model for MT-mediated CdSe nanoparticle toxicity is proposed.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Trace Elements in Health · Nanocluster Synthesis and Applications · Nanoparticles: synthesis and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (35)
Show source-provided references
1. 10.1146/annurev.bioeng.7.060804.10043210.1146/annurev.bioeng.7.060804.100432 ↗
2. 10.1016/j.copbio.2004.11.00310.1016/j.copbio.2004.11.003 ↗
3. 10.1038/nmat139010.1038/nmat1390 ↗
4. 10.1021/nl034733410.1021/nl0347334 ↗
5. 10.1021/nl048715d10.1021/nl048715d ↗
6. 10.1021/nl047996m10.1021/nl047996m ↗
7. 10.1016/j.chembiol.2005.09.00810.1016/j.chembiol.2005.09.008 ↗
8. 10.1021/nl025504510.1021/nl0255045 ↗
9. 10.1002/smll.20050010510.1002/smll.200500105 ↗
10. 10.1039/b413175d10.1039/b413175d ↗
11. 10.1016/S0010-8545(02)00176-510.1016/S0010-8545(02)00176-5 ↗
12. 10.1021/cr020620d10.1021/cr020620d ↗
13. 10.1016/S0162-0134(01)00347-610.1016/S0162-0134(01)00347-6 ↗
14. 10.1046/j.1471-4159.2000.0751878.x10.1046/j.1471-4159.2000.0751878.x ↗
15. 10.1016/S0002-9440(10)63514-610.1016/S0002-9440(10)63514-6 ↗
16. 10.1093/toxsci/kfg09510.1093/toxsci/kfg095 ↗
17. Wang G. W. · J. Pharmacol. Exp. Ther. · 2001 · 298 · 46110.1016/S0022-3565(24)29403-9 ↗
18. 10.1039/b501315a10.1039/b501315a ↗
19. 10.1021/ja054166h10.1021/ja054166h ↗
20. 10.1039/B511591D10.1039/B511591D ↗
21. 10.1126/science.278.5346.211410.1126/science.278.5346.2114 ↗
22. 10.1021/ar970032010.1021/ar9700320 ↗
23. 10.1021/jp046072k10.1021/jp046072k ↗
24. 10.1021/la981505u10.1021/la981505u ↗
25. 10.1016/0022-2836(91)90933-W10.1016/0022-2836(91)90933-W ↗
26. 10.1002/prot.1005010.1002/prot.10050 ↗
27. 10.1016/S0969-2126(03)00044-310.1016/S0969-2126(03)00044-3 ↗
28. 10.1016/S0021-9258(18)64017-710.1016/S0021-9258(18)64017-7 ↗
29. 10.1021/ja042591p10.1021/ja042591p ↗
30. 10.1021/ja039686w10.1021/ja039686w ↗
31. 10.1016/S1367-5931(00)00082-X10.1016/S1367-5931(00)00082-X ↗
32. 10.1016/j.cbpa.2005.09.01210.1016/j.cbpa.2005.09.012 ↗
33. 10.1021/nl034786l10.1021/nl034786l ↗
34. 10.1021/ja003633m10.1021/ja003633m ↗
35. 10.1016/0003-2697(79)90792-910.1016/0003-2697(79)90792-9 ↗