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journal article·2025-01Open access

Polyphenol‐Scaffolded Modular Assembly of Heterotypic Cell–Cell Assemblies for Potentiating Cancer Immunotherapy

Guidong Gong, Qimin Yin, Qinling Liu, Yajing Zhang, Jinyuan Liu, Mengyuan Dai, Jiawen Li, Xianglian He, Jiezhou Pan, Yunxiang He, Bo Wang, Jiyu Tong, Junling Guo

Small· Volume 21· Issue 4
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Abstract

Abstract Cells existing in the form of clusters often exhibit distinct biological functions from their single‐cell counterparts. However, the ability to modulate cell–cell interactions among multiple cell types through molecular scaffolds remains an ongoing challenge. Here, a supramolecular phenolic network on surfaces of live cells designed is engineered to act as modular scaffolds that promote intercellular interactions, presenting a universal platform for the construction of cell–cell assemblies (CCAs). Utilizing the inherent cell surface affinity of supramolecular phenolic network modules, a series of heterotypic CCAs is efficiently established by assembling five distinct microorganisms and five types of mammalian cells. A specific application of CCAs with the combination of L. casei and macrophages (L. casei@Mφ) is highlighted for enhanced cancer immunotherapy. Upon intravenous administration, L. casei@Mφ allows the chemotactic Mφ to facilitate the accumulation of L. casei at the tumor. The accumulated L. casei enables the polarization of tumor‐associated Mφ toward a pro‐inflammatory phenotype, markedly improving the immunotherapeutic response, slowing tumor progression, and mitigating lung metastasis. This work demonstrates the potential of polyphenol‐scaffolded modular assembly in manipulating cell–cell interactions to enhance multicellular cooperation, offering a general approach to controlling complex cellular behaviors.
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Research context

OpenAlex topics: 3D Printing in Biomedical Research · Nanoplatforms for cancer theranostics · Tissue Engineering and Regenerative Medicine

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

BMI Center for Biomass Materials and Nanointerfaces National Engineering Laboratory for Clean Technology of Leather Manufacture Ministry of Education Key Laboratory of Leather Chemistry and Engineering College of Biomass Science and Engineering Sichuan University Chengdu Sichuan 610065 China

Institute of Cardiovascular Surgery The Second Affiliated Hospital Army Medical University Chongqing 400037 China

Ministry of Education Children's Medicine Key Laboratory of Sichuan Province West China Second University Hospital Sichuan University Chengdu Sichuan 610041 China

Department of Immunology West China School of Basic Medical Sciences and Forensic Medicine Sichuan University Chengdu Sichuan 610041 China

Tea Refining and Innovation Key Laboratory of Sichuan Province College of Horticulture Sichuan Agricultural University Chengdu Sichuan 611130 China

CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic Biology Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China

Department of Chemical and Biological Engineering University of British Columbia Vancouver BC V6T 1Z4 Canada

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China · State Key Laboratory of Polymer Materials Engineering · Natural Science Foundation of Sichuan Province

References (45)

Show source-provided references
1. 10.1038/s41586-023-06052-110.1038/s41586-023-06052-1 ↗
2. 10.1038/s41586-023-06300-410.1038/s41586-023-06300-4 ↗
3. 10.1038/s41467-019-12472-310.1038/s41467-019-12472-3 ↗
4. 10.1038/s41568-022-00491-010.1038/s41568-022-00491-0 ↗
5. 10.1038/s41573-022-00520-510.1038/s41573-022-00520-5 ↗
6. 10.1038/s41586-022-05622-z10.1038/s41586-022-05622-z ↗
7. 10.1038/s41579-020-0433-910.1038/s41579-020-0433-9 ↗
8. 10.1038/s41467-023-43161-x10.1038/s41467-023-43161-x ↗
9. 10.1021/acs.chemrev.7b0015710.1021/acs.chemrev.7b00157 ↗
10. 10.1021/jacs.0c1124510.1021/jacs.0c11245 ↗
11. 10.1038/s41587-022-01244-y10.1038/s41587-022-01244-y ↗
12. 10.1038/s41565-023-01333-210.1038/s41565-023-01333-2 ↗
13. 10.1002/adma.20230538410.1002/adma.202305384 ↗
14. 10.1038/s41563-023-01646-610.1038/s41563-023-01646-6 ↗
15. 10.1038/s41551-024-01180-z10.1038/s41551-024-01180-z ↗
16. 10.1038/s41577-019-0210-z10.1038/s41577-019-0210-z ↗
17. 10.1038/s41467-024-46793-910.1038/s41467-024-46793-9 ↗
18. 10.1038/s41586-024-07443-810.1038/s41586-024-07443-8 ↗
19. 10.1038/s41586-024-07237-y10.1038/s41586-024-07237-y ↗
20. 10.1021/acsnano.2c1070410.1021/acsnano.2c10704 ↗
21. 10.1038/s41579-023-00942-x10.1038/s41579-023-00942-x ↗
22. 10.1038/s41586-022-05223-w10.1038/s41586-022-05223-w ↗
23. 10.1126/science.123726510.1126/science.1237265 ↗
24. 10.1002/anie.20131113610.1002/anie.201311136 ↗
25. 10.1038/nnano.2016.17210.1038/nnano.2016.172 ↗
26. 10.1126/science.aat977710.1126/science.aat9777 ↗
27. 10.1038/s41467-022-29672-z10.1038/s41467-022-29672-z ↗
28. 10.1002/adma.20200349210.1002/adma.202003492 ↗
29. 10.1016/j.matt.2022.09.02110.1016/j.matt.2022.09.021 ↗
30. 10.1126/sciadv.abh348210.1126/sciadv.abh3482 ↗
31. 10.1002/anie.20230346310.1002/anie.202303463 ↗
32. 10.1002/adma.20200205410.1002/adma.202002054 ↗
33. 10.1126/sciadv.aaz657910.1126/sciadv.aaz6579 ↗
34. 10.1038/s41551-020-00644-210.1038/s41551-020-00644-2 ↗
35. 10.1126/sciadv.aaz610510.1126/sciadv.aaz6105 ↗
36. 10.1038/s41577-019-0124-910.1038/s41577-019-0124-9 ↗
37. 10.1038/s41577-019-0127-610.1038/s41577-019-0127-6 ↗
38. 10.1038/s44222-022-00004-610.1038/s44222-022-00004-6 ↗
39. 10.1002/adma.20210349710.1002/adma.202103497 ↗
40. 10.1038/s41586-022-05435-010.1038/s41586-022-05435-0 ↗
41. 10.1126/science.aay918910.1126/science.aay9189 ↗
42. 10.1038/s41578-021-00362-410.1038/s41578-021-00362-4 ↗
43. 10.1016/j.addr.2023.11482510.1016/j.addr.2023.114825 ↗
44. 10.1038/s41392-022-00894-310.1038/s41392-022-00894-3 ↗
45. 10.1002/adma.20210484910.1002/adma.202104849 ↗