DataVXSmallPaper
journal article·2024-11

A Simple Binary Supramolecular Co‐Assembly Platform for Enhanced Tumor Imaging and Therapy

Yifan Huang, Cheng Chen, Zian Yu, Wei Cao, Shengjie Peng, Guangtao Zhang, Qianzijing Zhang, Guozhen Zhang, Jun Jiang, Yue Yuan

Small· Volume 20· Issue 47
Publisher page
Source abstract

Abstract

Abstract The primary challenges in tumor imaging and therapy revolve around improving targeting efficiency, enhancing probe/drug delivery efficacy, and minimizing off‐target signals and toxicity. Although various carriers have been developed, many are difficult to synthesize, costly, and not universally applicable. Furthermore, numerous carriers exhibit limited delivery rates in solid tumors, particularly larger nanocarriers. To address these challenges, a simple binary co‐assembly drug delivery platform has been designed using the readily synthesized small molecule Cys(SEt)‐Lys‐CBT ( CKCBT ) as the self‐assembly building block. CKCBT can effectively penetrate tumor cells due to its positively charged Lys side chain and small size. Upon glutathione reduction, CKCBT co‐assembles with Nile red or Chlorin e6 to form nanofibers inside tumor cells. This enables their specific accumulation in tumor cells rather than normal cells and extends their exposure time, resulting in precise and enhanced tumor imaging and treatment. Hence, this uncomplicated and highly efficient binary co‐assembly drug delivery platform can be easily adapted to a broad spectrum of probes and drugs, presenting a novel approach for advancing clinical diagnosis and therapy.
Source: crossref · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Supramolecular Self-Assembly in Materials · Metal-Organic Frameworks: Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Neurosurgery The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China Hefei Anhui 230031 China

Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of China Hefei Anhui 230026 China

Department of Radiation Oncology The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China Hefei Anhui 230031 China

Anhui Province Key Laboratory of Medical Physics and Technology Institute of Health and Medical Technology Hefei Institutes of Physical Science Chinese Academy of Sciences Hefei Anhui 230088 China

Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China Hefei Anhui 230026 China

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China · Fundamental Research Funds for the Central Universities

References (32)

Show source-provided references
1. 10.1039/C4CS00333K10.1039/C4CS00333K ↗
2. 10.1039/D1CS01074C10.1039/D1CS01074C ↗
3. 10.1038/s41392-023-01668-110.1038/s41392-023-01668-1 ↗
4. 10.1038/nnano.2007.38710.1038/nnano.2007.387 ↗
5. 10.1038/s41573-020-0090-810.1038/s41573-020-0090-8 ↗
6. 10.1038/natrevmats.2016.1410.1038/natrevmats.2016.14 ↗
7. 10.1038/nmat471810.1038/nmat4718 ↗
8. 10.1002/adma.20150259810.1002/adma.201502598 ↗
9. 10.1038/s41563-019-0503-410.1038/s41563-019-0503-4 ↗
10. 10.1021/jacs.6b0607510.1021/jacs.6b06075 ↗
11. 10.1021/jacs.3c1025510.1021/jacs.3c10255 ↗
12. 10.1002/anie.20171023710.1002/anie.201710237 ↗
13. 10.1021/jacs.2c1318910.1021/jacs.2c13189 ↗
14. 10.1039/C7CS00391A10.1039/C7CS00391A ↗
15. 10.1016/j.nantod.2016.02.00410.1016/j.nantod.2016.02.004 ↗
16. 10.1021/acsnano.6b0158710.1021/acsnano.6b01587 ↗
17. 10.1039/C4NR04039B10.1039/C4NR04039B ↗
18. 10.1021/acs.accounts.8b0031210.1021/acs.accounts.8b00312 ↗
19. 10.1002/smll.20231135110.1002/smll.202311351 ↗
20. 10.1038/s41565-020-0759-510.1038/s41565-020-0759-5 ↗
21. 10.1038/nnano.2008.3010.1038/nnano.2008.30 ↗
22. 10.1038/s41563-023-01630-010.1038/s41563-023-01630-0 ↗
23. 10.1039/C6RA28654B10.1039/C6RA28654B ↗
24. 10.1002/anie.20200778610.1002/anie.202007786 ↗
25. 10.1021/nn401168610.1021/nn4011686 ↗
26. 10.1002/advs.20200108810.1002/advs.202001088 ↗
27. 10.1021/acsnano.0c0342110.1021/acsnano.0c03421 ↗
28. 10.1002/adfm.20170631010.1002/adfm.201706310 ↗
29. 10.1002/anie.20090362710.1002/anie.200903627 ↗
30. 10.1038/nchem.48010.1038/nchem.480 ↗
31. 10.1021/acsomega.8b0250310.1021/acsomega.8b02503 ↗
32. 10.2147/IJN.S38899610.2147/IJN.S388996 ↗