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journal article·2023-06Open access

A Selective Nano Cell Cycle Checkpoint Inhibitor Overcomes Leukemia Chemoresistance (Small 25/2023)

Jie Sun, Fan Xia, Shaoqi Zhang, Bo Zhang, Yunan Guan, Xi Hu, Pengpeng Xue, Shengfei Yang, Yan Zhou, Daishun Ling, Fangyuan Li

Small· Volume 19· Issue 25
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Source abstract

Abstract

Nano Cell Cycle Checkpoint Inhibitors In article number 2300736, Daishun Ling, Fangyuan Li, and co-workers demonstrate that ultra-small iron oxide nanoparticles (IONPs) can serve as a selective nano cell cycle checkpoint inhibitor (NCCI) to catalyze the intracellular H2O2 into abundant ·OH, cleave heat shock protein 90 (Hsp90), and thus induce the degradation of the client protein ATR/CHK1, leading to the dysfunction of the G2/M checkpoint in acute myeloid leukemia (AML) cells. As a result, NCCI can interfere with the chemotherapy-induced DNA damage repair, which effectively reverses the chemoresistance of acute myeloid leukemia.
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Research context

NanomaterialsCatalysis & surfaces

OpenAlex topics: PARP inhibition in cancer therapy · Radiation Therapy and Dosimetry · Health Systems, Economic Evaluations, Quality of Life

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Affiliations

Bone Marrow Transplantation Center the First Affiliated Hospital Zhejiang University School of Medicine Liangzhu LaboratoryZhejiang University Medical CenterInstitute of Hematology Zhejiang University Hangzhou 310058 China

Institute of Pharmaceutics Hangzhou Institute of Innovative Medicine College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China

Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical Engineering National Center for Translational Medicine State Key Laboratory of Oncogenes and Related Genes Shanghai Jiao Tong University Shanghai 200240 China

WLA Laboratories Shanghai 201203 China

School of Pharmacy Anhui University of Chinese Medicine Hefei 230012 China

Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Hangzhou 310009 China

References

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