Logic Gates: Simple and Universal Platform for Logic Gate Operations Based on Molecular Beacon Probes (Small 14/2012)

The cover picture illustrates how the hairpin-structured molecular beacon probe interacts with DNA input and generates a high fluorescence signal through a sequencespecific hybridization, as demonstrated by H. G. Park and co-workers on page 2203. By employing this molecular beacon probe as a basic work unit and rationally designing a series of DNA inputs, a new universal platform technology for molecular logic gates is demonstrated, which achieves not only a complete set of two-input logic gates, but also gate wiring in multilevel circuits and the reversible modulation of logic gates. This work holds great promise for applications in molecular computing and bioelectronics.