DataVXSmallPaper
journal article·2023-10Open access

Nanofluidic Aptamer Nanoarray to Enable Stochastic Capture of Single Proteins at Normal Concentrations (Small 43/2023)

Jinbin Yang, Hiroki Kamai, Yong Wang, Yan Xu

Small· Volume 19· Issue 43
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Source abstract

Abstract

Nanofluidic Devices A nanofluidic aptamer nanoarray (NANa) enables the stochastic capture of single proteins at normal high concentrations from samples with ultrasmall volumes equivalent to a single cell by following Poisson statistics, forming a readily addressable single-protein nanoarray. This approach offers a methodology and device that surpass both the concentration and volume limits of single-protein capture in conventional single-molecule experiments, thereby opening an avenue to explore the behavior of individual cellular molecules in a manner closer to their natural forms—a realm that has remained largely unexplored to date. More details can be found in article number 2301013 by Yan Xu and co-workers.
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Research context

Nanomaterials

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Microfluidic and Bio-sensing Technologies · Microfluidic and Capillary Electrophoresis Applications

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Affiliations

Department of Chemical Engineering Graduate School of Engineering Osaka Prefecture University 1–2, Gakuen‐cho, Naka‐ku, Sakai Osaka 599‐8570 Japan

Department of Biomedical Engineering The Pennsylvania State University 26 CBEB University Park PA 16802‐6804 USA

Department of Chemical Engineering Graduate School of Engineering Osaka Metropolitan University 1–2, Gakuen‐cho, Naka‐ku, Sakai Osaka 599‐8570 Japan

Japan Science and Technology Agency (JST) PRESTO, 4‐1‐8 Honcho Kawaguchi Saitama 332‐0012 Japan

Japan Science and Technology Agency (JST) CREST, 4‐1‐8 Honcho Kawaguchi Saitama 332‐0012 Japan <?vsp 42pt?>

References

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