Elastic Nanovaccine Enhances Dendritic Cell‐Mediated Tumor Immunotherapy (Small 32/2022)
Source abstract
Abstract
Elastic Nanovaccines In article number 2201108, Zhaogang Teng, Heng Dong, Yongbin Mou, and co-workers report a soft mesoporous organosilica-based nanovaccine (SMONV) and demonstrate that elastic SMONV evokes robust antitumor immune cascades, including lymphatic drainage, antigen internalization and cross-presentation, and tumor-specific T-cell immune responses. Treg-mediated immunosuppression is inhibited after immunization with SMONV. Furthermore, combined administration of anti-PD-L1 antibodies induces tumor regression. The paper provides insight into nanoparticle elasticity and dendritic cell-mediated immunotherapy.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Cancer Immunotherapy and Biomarkers · Nanoplatforms for cancer theranostics · Cancer Research and Treatments
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Affiliations
Nanjing Stomatological Hospital Medical School of Nanjing University 30 Zhongyang Road Nanjing Jiangsu 210008 P. R. China
Key Laboratory for Organic Electronics and Information Displays Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials Jiangsu National Synergetic Innovation Centre for Advanced Materials Nanjing University of Posts and Telecommunications 9 Wenyuan Road Nanjing Jiangsu 210023 P. R. China
References
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