DataVXSmallPaper
journal article·2021-12

Biointerfacing Antagonizing T‐Cell Inhibitory Nanoparticles Potentiate Hepatocellular Carcinoma Checkpoint Blockade Therapy (Small 51/2021)

Han Wu, Jia‐Qi Zhu, Xin‐Fei Xu, Hao Xing, Ming‐Da Wang, Lei Liang, Chao Li, Hang‐Dong Jia, Feng Shen, Dong‐Sheng Huang, Tian Yang

Small· Volume 17· Issue 51
Publisher page
Source abstract

Abstract

Biointerfacing Nanoparticles In article number 2105237, Dong-Sheng Huang, Tian Yang, and co-workers develop a strategy of targeting therapeutic nanoparticles effectively reversing the immune-inhibiting microenvironment for enhanced PD-L1 checkpoint combination therapy. The platelet membrane cloaked nanoparticles activate the CD8+ T lymphocytes and antigen presentation of dendritic cells as well as the polarization of M1-type macrophages with the application of TIM-3 antibodies. With the collagen deposition, starvation therapy can enhance the efficacy of immunotherapy under a hypoxic microenvironment.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsMaterials processing

OpenAlex topics: Immune cells in cancer · Cancer Immunotherapy and Biomarkers · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College) Hangzhou 310014 China

School of Clinical Medicine Hangzhou Medical College Hangzhou Zhejiang 310014 China

Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University (Naval Medical University) Shanghai 200438 China

Department of Hepatobiliary, Pancreatic and Minimal Invasive Surgery Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College) Hangzhou Zhejiang 310014 China

References

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