Chemo‐Immunotherapy: Sequential MR Image‐Guided Local Immune Checkpoint Blockade Cancer Immunotherapy Using Ferumoxytol Capped Ultralarge Pore Mesoporous Silica Carriers after Standard Chemotherapy (Small 52/2019)
Source abstract
Abstract
Ferumoxytol capped anti PD-L1 antibodies (aPD-L1) loaded ultra-large pore mesoporous silica nanoparticles (Fer-ICB-UPMSNPs) are delivered with image guidance after cabazitaxel (Cbz) chemotherapy for the treatment of prostate cancer. Sustained release of ICB from UPMSNP inhibits the immunosuppressive tumor microenvironment and activates tumor specific dendritic cells (DC). Activated antigen presenting cells educate the tumor specific naïve T cells, and cytotoxic T cells are infiltrated to the tumor for the regression. More details can be found in article number 1904378 by Dong-Hyun Kim and co-workers.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Immunotherapy and Immune Responses · Cancer Immunotherapy and Biomarkers
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Radiology Feinberg School of Medicine Northwestern University Chicago IL 60611 USA
Molecular Recognition Research Center Korea Institute of Science and Technology (KIST) Division of Nano and Information Technology KIST School Korea University of Science and Technology (UST) Seoul 02792 South Korea
Robert H. Lurie Comprehensive Cancer Center Chicago IL 60611 USA
Department of Biomedical Engineering McCormick School of Engineering Evanston IL 60208 USA
References
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