journal article·2019-09

Single Cell Genomics: Whole Genome Sequencing of Single Circulating Tumor Cells Isolated by Applying a Pulsed Laser to Cell‐Capturing Microstructures (Small 37/2019)

Okju Kim, Daewon Lee, Amos Chungwon Lee, Yongju Lee, Hyung Jong Bae, Han‐Byoel Lee, Ryong Nam Kim, Wonshik Han, Sunghoon Kwon

Small· Volume 15· Issue 37
Publisher page

Abstract

Isolating one rare cell in a second: Single circulating tumor cells (CTCs) within their protein expression contexts are analyzed through next generation sequencing for genome-wide analysis in article number 1902607 by Sunghoon Kwon and co-workers. Whole blood from a metastatic breast cancer patient is processed through a microfluidic chip. CTCs are selected via fluorescence imaging and the fluorescently stained CTCs are isolated with a near-infrared pulsed laser device without contact.
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Research context

OpenAlex topics: Cancer Cells and Metastasis

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Affiliations

Department of Electrical and Computer Engineering Institute of Engineering Research Seoul National University 1 Gwanak‐ro, Gwanak‐gu Seoul 08826 Republic of Korea

Interdisciplinary Program in Bioengineering Seoul National University 1 Gwanak‐ro Gwanak‐gu Seoul 08826 Republic of Korea

BK21+ Creative Research Engineer Development for IT Seoul National University 1 Gwanak‐ro, Gwanak‐gu Seoul 08826 Republic of Korea

Nano Systems Institute Seoul National University 1 Gwanak‐ro Gwanak‐gu Seoul 08826 Republic of Korea

Department of Surgery Seoul National University College of Medicine 101 Daehak‐ro, Jongno‐gu Seoul 03080 Republic of Korea

Biomedical Research Institute Seoul National University Hospital 101 Daehak‐ro, Jongno‐gu Seoul 03080 Republic of Korea

Cancer Research Institute Seoul National University 101 Daehak‐ro, Jongno‐gu Seoul 03080 Republic of Korea

Institutes of Entrepreneurial BioConvergence Seoul National University 1 Gwanak‐ro Gwanak‐gu Seoul 08826 Republic of Korea

Inter‐University Semiconductor Research Center 1 Gwanak‐ro, Gwanak‐gu Seoul 08826 Republic of Korea

References

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