Microfluidics: Simultaneous or Sequential Orthogonal Gradient Formation in a 3D Cell Culture Microfluidic Platform (Small 5/2016)
Source abstract
Abstract
The microfluidic designed by R. D. Kamm and co-workers allow the formation of simultaneous or sequential concentration gradients within a 3D extracellular matrix. On page 612, these gradients can be used to investigate biological phenomena, such as the differentiation of progenitor cells into neurons as it occurs within the developing spinal cord, or the dynamics of chemotaxis when cells are exposed to time-dependent concentration profiles.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: 3D Printing in Biomedical Research
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Affiliations
Department of Mechanical Engineering Massachusetts Institute of Technology (MIT) Cambridge MA 02139 USA
Harvard‐MIT Health Sciences and Technology Cambridge MA 02139 USA
Department of Stem Cell and Regenerative Biology Harvard University and Brigham and Women's Hospital Cambridge MA 02138 USA
Department of Biological Engineering Massachusetts Institute of Technology (MIT) Cambridge MA 02139 USA
References
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