Serrs: Plasmonic Nanostructures for SERRS Multiplexed Identification of Tumor‐Associated Antigens (Small 24/2012)

Gold nanostructures, obtained by centrifugal aggregation of nanoparticles synthesized by laser ablation in solution, are functionalized with different SERRS reporters and with different associated antibodies by M. Meneghetti, M. Colombatti and co-workers on page 3733. Prostatic cancer cells expressing one of two antigens (PSMA or PSCA) or both are targeted by specific antibodies and are easily recognized in SERRS spectra of the reporters associated to the antibodies. The presence of both antigens is recognized on the same cell with only one spectrum, realizing SERRS multiplexing.