DataVXSmallPaper
journal article·2023-10Open access

Systemic Delivery of a STING Agonist‐Loaded Positively Charged Liposome Selectively Targets Tumor Immune Microenvironment and Suppresses Tumor Angiogenesis (Small 43/2023)

Eun‐Jin Go, Hannah Yang, Wooram Park, Seung Joon Lee, Jun‐Hyeok Han, So Jung Kong, Won Suk Lee, Dong Keun Han, Hong Jae Chon, Chan Kim

Small· Volume 19· Issue 43
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Source abstract

Abstract

Positively Charged Liposomes Systemic delivery of positively charged fusogenic liposomes loaded with a stimulator of interferon genes (STING) agonist (PoSTING) selectively targets the tumor microenvironment and suppresses aberrant tumor angiogenesis. PoSTING can convert non-inflamed cold tumors (upper) into inflamed hot tumors (lower) by normalizing tumor blood vessels (red) and promoting CD8+ T cell infiltration (green) into the tumors. More details can be found in article number 2300544 by Dong Keun Han, Hong Jae Chon, Chan Kim, and co-workers.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: interferon and immune responses · Cancer Research and Treatments · Nanoplatforms for cancer theranostics

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Affiliations

Medical Oncology CHA Bundang Medical Center CHA University School of Medicine Seongnam Gyeonggi 13496 Republic of Korea

Laboratory of Translational Immuno‐Oncology CHA University School of Medicine Seongnam Gyeonggi 13496 Republic of Korea

Department of Integrative Biotechnology College of Biotechnology and Bioengineering Sungkyunkwan University Seoburo 2066 Suwon Gyeonggi 16419 Republic of Korea

Department of Biomedical Science CHA University Seongnam Gyeonggi 13496 Republic of Korea

References

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