journal article·2022-09Open access

In Vivo Kidney Allograft Endothelial Specific Scavengers for On‐Site Inflammation Reduction under Antibody‐Mediated Rejection

Chang Liu, Pengpeng Yan, Xiaoyu Xu, Wenhui Zhou, Dhayakumar Rajan Prakash, Shuqi Wang, Junnian Zhou, Rending Wang, Hongfeng Huang, Jianghua Chen, Hongbo Zhang, Jia Shen

Small· Volume 18· Issue 36

Abstract

Abstract Kidney transplantation is the most effective therapy for patients with end‐stage renal disease. However, antibody‐mediated rejection (ABMR) threatens long‐term survival of renal grafts. Although ABMR can be controlled by donor‐specific antibody clearance and B‐ or (and) plasma‐cells inhibition, the treatment often causes severe side effects in patients. Therefore, there is need to explore site‐specific scavengers. In this study, a nanovehicle carrying an anti‐inflammatory drug is developed with complement component 4d targeting, a specific biomarker expressed on allograft endothelium under ABMR. Moreover, the nanovehicle is endowed with photothermal properties to control drug release. Analysis through systematic in vitro and in vivo toxicity, non‐invasive targeted imaging, and in situ remote controlled drug release show the nanovehicle specifically targets allograft kidney endothelium, releases an anti‐inflammatory drug, methylprednisolone, locally upon laser irradiation, and promotes recovery of injured endothelium, without affecting systemic inflammation or innate immune responses. This strategy has the potential for future clinical application in ABMR treatment.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanoplatforms for cancer theranostics · Renal Transplantation Outcomes and Treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Kidney Disease Center The First Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310003 China

Pharmaceutical Sciences Laboratory Åbo Akademi University Turku 20520 Finland

Turku Bioscience Centre University of Turku and Åbo Akademi University Turku 20520 Finland

ENT institute and Department of Otorhinolaryngology Eye & ENT Hospital State Key Laboratory of Medical Neurobiology Institutes of Biomedical Sciences Fudan University Shanghai 200031 China

Institute for Translational Medicine Zhejiang University Hangzhou Zhejiang Province 310029 China

Experimental Hematology and Biochemistry Lab Beijing Institute of Radiation Medicine Beijing 100850 China

Stem Cell and Regenerative Medicine Lab Institute of Health Service and Transfusion Medicine Beijing 100850 China

Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

Funding

National Natural Science Foundation of China · Academy of Finland · Sigrid Juséliuksen Säätiö

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