Mechanical Stimulation after Centrifuge‐Free Nano‐Electroporative Transfection Is Efficient and Maintains Long‐Term T Cell Functionalities (Small 38/2021)
Source abstract
Abstract
Transfection In article number 2103198, Andy Tay and Nicholas Melosh illustrate the use of high aspect-ratio hollow nanostructures coupled with transient electroporation for electrophoretic delivery of DNA into T cell. Magnetic stimulation was added subsequently to enhance intracellular DNA transport towards the nucleus to achieve high transfection efficiency. Facilitated by magnetic manipulation, the whole gene delivery process is centrifuge-free, making it compatible with end-to-end cell manufacturing.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: RNA Interference and Gene Delivery
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Affiliations
Department of Biomedical Engineering National University of Singapore Singapore 117583 Singapore
Institute of Health Innovation & Technology National University of Singapore Singapore 117599 Singapore
Department of Materials Science and Engineering Stanford University Stanford CA 94305 USA
References
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