Vaccine Adjuvants: Efficient and Durable Vaccine against Intimin β of Diarrheagenic E. Coli Induced by Clay Nanoparticles (Small 12/2016)

On page 1627, layered double hydroxide (hexagonal) and hectorite (sheet) nanoparticles are demonstrated to be promising vaccine adjuvants by T. Mahony, Z. P. Xu, and co-workers. The nanoparticles induce sustained, high levels of specific antibodies (IgG and IgA) and a strong cell-mediated response (IFN-γ), in comparison with the commonly-used adjuvant QuilA. Their high adjuvanticity could be attributed to the high antigen loading, facilitation to the antigen cellular uptake and the depot effect.