Nanoporous Gold Channel with Attached DNA Nanolock for Drug Screening

Soft matter, easily deformed by weak interactions, can act as a sensing element based on stimuli-responsive conformational change. When combined with solid-state nanomaterials, the mechanical actuation is transformed into an optical or electrical signal. DNA molecules can control the pore accessibility of nanoporous gold, acting as a smart nanolock. Application in the screening of anticancer drugs is demonstrated. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.