DataVXSmallPaper
journal article·2016-01Open access

DNA Origami: Daunorubicin‐Loaded DNA Origami Nanostructures Circumvent Drug‐Resistance Mechanisms in a Leukemia Model (Small 3/2016)

Patrick D. Halley, Christopher R. Lucas, Emily M. McWilliams, Matthew J. Webber, Randy A. Patton, Comert. Kural, David M. Lucas, John C. Byrd, Carlos E. Castro

Small· Volume 12· Issue 3
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Source abstract

Abstract

DNA origami “Trojan horse” nanostructures provide an effective delivery approach to circumvent drug resistance in leukemia cells. These 100 nanometer delivery vehicles, described on page 308 by C. E. Castro and co-workers, are easily fabricated in 10 min and can be precisely loaded with commonly used anthracycline chemotherapeutic drugs. Drug-loaded DNA origami nanostructures enter cells via endocytosis, allowing the drug to bypass defenses in the cell membrane that are effective against free drug. This approach leads to larger amounts of drug in cells, which is later released due to decreasing pH and enzymatic degradation, ultimately improving drug efficacy.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Advanced biosensing and bioanalysis techniques · RNA Interference and Gene Delivery · Graphene and Nanomaterials Applications

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Affiliations

Department of Mechanical and Aerospace Engineering College of Engineering The Ohio State University Columbus OH 43210 USA

Department of Chemical and Biomolecular Engineering College of Engineering The Ohio State University Columbus OH 43210 USA

Biomedical Sciences Graduate Program Department of Internal Medicine College of Medicine The Ohio State University Columbus OH 43210 USA

Biophysics Graduate Program The Ohio State University Columbus OH 43210 USA

Biophysics Graduate Program Department of Physics The Ohio State University Columbus OH 43210 USA

Department of Internal Medicine College of Medicine College of Pharmacy The Ohio State University Columbus OH 43210 USA

Department of Mechanical and Aerospace Engineering College of Engineering Biophysics Graduate Program The Ohio State University Columbus OH 43210 USA

References

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