An Entropic Force Microscope Enables Nano‐Scale Conformational Probing of Biomolecules

Inherently disordered dynamics governing macromolecular transport under nanoconfined surroundings can paradoxically be precisely controlled. This capability lays a foundation for a sensitive probe of nanoscale molecular conformation, revealing previously unseen details about DNA-protein binding interactions at size scales below the limits of most conventional techniques. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.