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journal article·2026-04

Dual Therapeutic Effects of Ultra‐Small Platinum‐Selenium Nanoparticles on Oxalate‐Induced Acute Kidney Injury

Nannan Zheng, Qiuyue Ma, Renkai Zhang, Jikang Zhang, Qinghui Wang, Yuxin He, Bin Yang, Stefanie Steiger, Liangcan He, Shaoqin Liu

Small· Volume 22· Issue 20
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Source abstract

Abstract

ABSTRACT Serum oxalate levels can rapidly increase due to specific dietary factors or ethylene glycol exposure, triggering acute kidney injury (AKI). Disorders like nephrocalcinosis and calcium oxalate (CaOx) nephropathy cause inflammation and renal failure without effective therapy. To address this challenge, ultra‐small platinum‐selenium (Pt‐Se) nanoparticles (NPs) were synthesized to inhibit CaOxcrystallization by adsorbing C 2 O 4 2− to block nucleation and by binding to crystal growth sites. in vitro and in vivo studies were performed to assess the inhibition of CaOx crystallization and oxalate‐induced AKI. Pt‐Se NPs not only suppressed CaOx crystallization but also inhibited crystal‐cell interactions, thereby reducing CaOx‐induced cell damage. Furthermore, in a hyperoxaluria mouse model, these NPs significantly decreased renal CaOx crystal deposition and attenuated kidney injury with excellent biocompatibility. In conclusion, ultra‐small Pt‐Se NPs represent a promising therapeutic strategy for acute CaOx crystal‐induced nephropathy.
Source: crossref · Quality: baseline

Research context

NanomaterialsBiomaterialsMaterials processing

OpenAlex topics: Kidney Stones and Urolithiasis Treatments · Chemotherapy-induced organ toxicity mitigation · Silymarin and Mushroom Poisoning

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Medicine and Health Harbin Institute of Technology Key Laboratory of Microsystems and Microstructures Manufacturing (Ministry of Education) Harbin China

Zhengzhou Research Institute Harbin Institute of Technology Zhengzhou China

State Key Laboratory of Woody Oil Resources Utilization Northeast Forestry University Harbin China

Key Laboratory of Forest Plant Ecology Ministry of Education Engineering Research Center of Forest Bio‐Preparation College of Chemistry Chemical Engineering and Resource Utilization Northeast Forestry University Harbin China

Functional Materials and Acoustooptic Instruments Institute School of Instrumentation Science and Engineering Harbin Institute of Technology Harbin China

Division of Nephrology Department of Medicine IV University Hospital Ludwig‐Maximilians‐University (LMU) Munich Munich Germany

Funding

Fundamental Research Funds for the Central Universities · China Postdoctoral Science Foundation

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