DataVXSmallPaper
journal article·2026-04

Graphene Oxide Nanosheets as Direct Photosensitizers for Photodynamic Therapy in a Size‐Dependent Manner

Chenhao Yu, Shangyan Sui, Xiaotong Yu, Qianming Chen, Qiang Peng

Small· Volume 22· Issue 20
Publisher page
Source abstract

Abstract

ABSTRACT Photodynamic therapy (PDT) has shown great potential in anticancer treatment. Photosensitizer is a key element determining the efficiency of PDT, but its practical use is highly limited by some critical problems, such as low photostability and poor solubility. As such, developing novel photosensitizers is of great significance and importance for PDT. In this work, we report the size‐dependent photodynamic effect of graphene oxide (GO) nanosheets, which are commonly used as carriers for drug delivery. GO (200 µg/mL) with a large size up to ∼3500 nm showed little cytotoxicity to HSC‐3 cells (oral squamous cell carcinoma cell line) but caused the cell viability down to 8% under NIR irradiation due to the robust generation of intracellular reactive oxygen species (ROS). Large GO‐induced ROS generation is also significant even under hypoxia. Animal study shows that large GO even induced tumor ablation directly under a single NIR irradiation. Our findings indicate that GO is much more than a carrier but can also be a great photosensitizer when its size is large enough. This work paves the way for the potential applications of GO as the photosensitizer in PDT.
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Research context

Nanomaterials

OpenAlex topics: Graphene and Nanomaterials Applications · Carbon and Quantum Dots Applications · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu China

Department of Periodontology Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials Beijing China

Department of Orthodontics Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases &National Engineering Laboratory For Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials Beijing China

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