Triboelectric Wearable Devices for Wound Healing: Materials, Mechanisms, and Innovative Designs
Source abstract
Abstract
ABSTRACT Wound healing is one of the most complex processes in the human body, facing severe challenges such as bacterial infection, prolonged non‐healing of chronic wounds, and a lack of dynamic monitoring methods. Although traditional electrical stimulation (ES) therapy can improve healing outcomes by promoting angiogenesis, inhibiting infection, and accelerating tissue regeneration, its reliance on external power sources, rigid electrodes, and lack of real‐time feedback limit its clinical application. In recent years, triboelectric wearable devices (e.g., Triboelectric Nanogenerators, TENGs) based on triboelectric active materials have provided breakthrough solutions for intelligent wound management. This article systematically reviews the latest advances in triboelectric wearable devices for intelligent wound management. It first summarizes the types of triboelectric and electrode layer materials and structural design strategies, then elucidates the intrinsic mechanisms by which they promote cell proliferation and migration, angiogenesis, and assist wound healing. Furthermore, it explores their innovative applications in clinical settings, including combination with other treatment methods and integration with intelligent diagnostic platforms. Finally, addressing current challenges such as material stability, device integration design, and large‐scale production, future research directions are proposed to provide references for the optimization and clinical translation of intelligent wound management systems.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Advanced Sensor and Energy Harvesting Materials · Wound Healing and Treatments · Planarian Biology and Electrostimulation
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemical Engineering and Bioengineering Zhejiang University Hangzhou Zhejiang Province China
NanoBioMedical Centre Adam Mickiewicz University Poznan Poland
Universiti Kebangsaan Malaysia Bangi Selangor Malaysia
Faculty of Medicine Universiti Kebangsaan Malaysia Kuala Lumpur Malaysia
School of Aerospace Mechanical and Mechatronic Engineering The University of Sydney Sydney New South Wales Australia
Funding
National Natural Science Foundation of China
References (100+)
Show source-provided references
1. 10.3390/pharmaceutics1510250810.3390/pharmaceutics15102508 ↗
2. 10.1016/j.bioactmat.2025.05.03410.1016/j.bioactmat.2025.05.034 ↗
3. 10.1016/j.esci.2023.10022310.1016/j.esci.2023.100223 ↗
4. 10.1016/j.carbpol.2023.12103810.1016/j.carbpol.2023.121038 ↗
5. 10.1016/j.nanoen.2025.11094010.1016/j.nanoen.2025.110940 ↗
6. 10.1002/adma.20230719410.1002/adma.202307194 ↗
7. 10.1007/s40820‐023‐01081‐x10.1007/s40820‐023‐01081‐x ↗
8. 10.1016/j.nanoen.2017.06.01810.1016/j.nanoen.2017.06.018 ↗
9. 10.1016/j.addr.2018.09.01010.1016/j.addr.2018.09.010 ↗
10. 10.1016/j.nanoen.2021.10600410.1016/j.nanoen.2021.106004 ↗
11. 10.1002/adhm.20230347410.1002/adhm.202303474 ↗
12. 10.1016/j.nanoen.2024.11050110.1016/j.nanoen.2024.110501 ↗
13. 10.1016/j.nanoen.2024.10926010.1016/j.nanoen.2024.109260 ↗
14. 10.1021/acsami.4c0744610.1021/acsami.4c07446 ↗
15. 10.1016/j.nanoen.2021.10690610.1016/j.nanoen.2021.106906 ↗
16. 10.1016/j.matt.2023.03.00510.1016/j.matt.2023.03.005 ↗
17. 10.1038/s41467‐022‐34716‐510.1038/s41467‐022‐34716‐5 ↗
18. 10.1016/j.mtnano.2023.10031810.1016/j.mtnano.2023.100318 ↗
19. 10.1038/s43586-023-00220-310.1038/s43586-023-00220-3 ↗
20. 10.1039/D3EE01290E10.1039/D3EE01290E ↗
21. 10.34133/2019/109163210.34133/2019/1091632 ↗
22. 10.1002/aenm.20210367710.1002/aenm.202103677 ↗
23. 10.1002/aenm.20160050510.1002/aenm.201600505 ↗
24. 10.1002/adfm.20200558410.1002/adfm.202005584 ↗
25. 10.1016/j.nanoen.2021.10632910.1016/j.nanoen.2021.106329 ↗
26. 10.1002/adma.20231438010.1002/adma.202314380 ↗
27. 10.1021/acsami.0c0703710.1021/acsami.0c07037 ↗
28. 10.1016/j.mtbio.2025.10238310.1016/j.mtbio.2025.102383 ↗
29. 10.1038/ncomms937610.1038/ncomms9376 ↗
30. 10.1016/j.nanoen.2012.01.00410.1016/j.nanoen.2012.01.004 ↗
31. 10.1039/C4FD00159A10.1039/C4FD00159A ↗
32. 10.1016/j.nanoen.2025.11082510.1016/j.nanoen.2025.110825 ↗
33. 10.1016/j.nanoen.2023.10923410.1016/j.nanoen.2023.109234 ↗
34. 10.1016/j.nanoen.2024.10943310.1016/j.nanoen.2024.109433 ↗
35. 10.1002/adma.20242045910.1002/adma.202420459 ↗
36. 10.9790/4861-090301959910.9790/4861-0903019599 ↗
37. 10.1021/acsaelm.3c0129710.1021/acsaelm.3c01297 ↗
38. 10.1016/j.nanoen.2023.10900010.1016/j.nanoen.2023.109000 ↗
39. 10.1002/adma.20150429910.1002/adma.201504299 ↗
40. 10.1002/advs.20240401910.1002/advs.202404019 ↗
41. 10.1016/j.nanoen.2022.10741910.1016/j.nanoen.2022.107419 ↗
42. 10.1016/j.nanoen.2021.10679110.1016/j.nanoen.2021.106791 ↗
43. 10.1002/adma.20241820710.1002/adma.202418207 ↗
44. 10.1016/j.nanoen.2024.11028910.1016/j.nanoen.2024.110289 ↗
45. 10.1016/j.cclet.2023.10919610.1016/j.cclet.2023.109196 ↗
46. 10.1002/smtd.20220066410.1002/smtd.202200664 ↗
47. 10.1039/D0TA08642H10.1039/D0TA08642H ↗
48. 10.1016/j.nanoen.2024.10947210.1016/j.nanoen.2024.109472 ↗
49. 10.1002/adfm.20231379010.1002/adfm.202313790 ↗
50. 10.1016/j.biomaterials.2025.12360310.1016/j.biomaterials.2025.123603 ↗
51. 10.1007/s12613‐024‐2839‐210.1007/s12613‐024‐2839‐2 ↗
52. 10.1002/adfm.20210913910.1002/adfm.202109139 ↗
53. 10.1016/j.nanoen.2025.11070910.1016/j.nanoen.2025.110709 ↗
54. 10.1002/adfm.20221057110.1002/adfm.202210571 ↗
55. 10.1016/j.carbpol.2025.12330110.1016/j.carbpol.2025.123301 ↗
56. 10.1002/adma.20231069710.1002/adma.202310697 ↗
57. 10.1016/j.mtbio.2024.10104410.1016/j.mtbio.2024.101044 ↗
58. 10.1039/D2RA01088G10.1039/D2RA01088G ↗
59. 10.1016/j.nanoen.2025.11124210.1016/j.nanoen.2025.111242 ↗
60. 10.1002/adhm.20230436510.1002/adhm.202304365 ↗
61. 10.1002/adfm.20231682010.1002/adfm.202316820 ↗
62. 10.1016/j.nanoen.2022.10813710.1016/j.nanoen.2022.108137 ↗
63. 10.1016/j.nanoen.2023.10892810.1016/j.nanoen.2023.108928 ↗
64. 10.1016/j.apmate.2025.10034110.1016/j.apmate.2025.100341 ↗
65. 10.1016/j.nanoen.2025.11079010.1016/j.nanoen.2025.110790 ↗
66. 10.1016/j.mser.2025.10104910.1016/j.mser.2025.101049 ↗
67. 10.1016/j.cej.2025.16457010.1016/j.cej.2025.164570 ↗
68. 10.1016/j.nanoen.2025.11103610.1016/j.nanoen.2025.111036 ↗
69. 10.1016/j.mtener.2023.10143110.1016/j.mtener.2023.101431 ↗
70. 10.1016/j.nanoen.2018.11.01210.1016/j.nanoen.2018.11.012 ↗
71. 10.1016/j.nanoen.2023.10868810.1016/j.nanoen.2023.108688 ↗
72. 10.1016/j.cej.2025.15961410.1016/j.cej.2025.159614 ↗
73. 10.1016/j.cej.2025.16541810.1016/j.cej.2025.165418 ↗
74. 10.1016/j.nanoen.2025.11066010.1016/j.nanoen.2025.110660 ↗
75. 10.1016/j.nanoen.2018.08.04810.1016/j.nanoen.2018.08.048 ↗
76. 10.1002/adfm.20180368410.1002/adfm.201803684 ↗
77. 10.1021/acsami.3c0050010.1021/acsami.3c00500 ↗
78. 10.1016/j.nanoen.2021.10632710.1016/j.nanoen.2021.106327 ↗
79. 10.1016/j.nanoen.2024.10960110.1016/j.nanoen.2024.109601 ↗
80. 10.1002/adfm.20210492810.1002/adfm.202104928 ↗
81. 10.1021/acs.chemrev.0c0092310.1021/acs.chemrev.0c00923 ↗
82. 10.1002/adfm.20240972610.1002/adfm.202409726 ↗
83. 10.1021/cbe.4c0017710.1021/cbe.4c00177 ↗
84. 10.1021/cbe.4c0011010.1021/cbe.4c00110 ↗
85. 10.1002/adhm.20240167610.1002/adhm.202401676 ↗
86. 10.1126/sciadv.adc875810.1126/sciadv.adc8758 ↗
87. 10.1016/j.nanoen.2021.10646510.1016/j.nanoen.2021.106465 ↗
88. 10.1016/j.nanoen.2020.10546310.1016/j.nanoen.2020.105463 ↗
89. 10.1007/s40843-024-3120-x10.1007/s40843-024-3120-x ↗
90. 10.1016/j.nanoen.2024.11055810.1016/j.nanoen.2024.110558 ↗
91. 10.1016/j.nanoen.2023.10893210.1016/j.nanoen.2023.108932 ↗
92. 10.1021/acsnano.5c0258110.1021/acsnano.5c02581 ↗
93. 10.1002/adma.20180572210.1002/adma.201805722 ↗
94. 10.1002/smll.20210399710.1002/smll.202103997 ↗
95. 10.1039/C8NR02192A10.1039/C8NR02192A ↗
96. 10.1038/s41528‐025‐00473‐w10.1038/s41528‐025‐00473‐w ↗
97. 10.1002/advs.20220150710.1002/advs.202201507 ↗
98. 10.1016/j.nanoen.2024.10958510.1016/j.nanoen.2024.109585 ↗
99. Smart Battery‐Free and Wireless Bioelectronic Platform Based on a Nature‐Skin‐Derived Organohydrogel for Chronic Wound Diagnosis
100. 10.1002/adma.20220905410.1002/adma.202209054 ↗