journal article·2025-12Open access

Shaping Magnetic Hyperthermia Properties through Nanoparticle Surface‐Ligand Design: Implications for Cellular Responses

Lukas Hertle, Alberto López‐Ortega, Hao Ye, Alba Martínez‐Jiménez de Allo, Eneko Garaio, Valentin Gantenbein, Joaquim Llacer‐Wintle, Ishika Paul, Sarina Nigg, Josep Puigmartí‐Luis, Marta Estrader, Xiang‐Zhong Chen, Bradley J. Nelson, Salvador Pané

Small· Volume 21· Issue 50

Abstract

Abstract Magnetic iron oxide nanoparticles have attracted increasing attention for their potential use in biomedicine over the last few decades. Their inherent characteristics have enabled novel therapeutic approaches such as magnetic hyperthermia. To maximize the therapeutic efficacy, several research efforts have been focused on the optimization of these nanoparticles in terms of their size, morphology, and crystal structure etc. However, no consensus has been reached regarding the optimal surface design. To gain deeper insight into this complex phenomenon, the influence of a variety of surface ligands on the magnetic, hyperthermic, and colloidal behaviors of the magnetic iron oxide nanoparticles, along with their influence on cellular viability, is investigated. The results revealed that the molecular structure of the ligands, including both the anchoring group and molecular chain, plays a critical role in determining the above‐mentioned properties and performance. This work lays the groundwork for surface engineering of magnetic nanoparticles, emphasizing the need to consider the magneto‐hyperthermic performance, colloidal stabilities, and the cellular interactions as interconnected factors that critically influence their clinical applicability.
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Research context

OpenAlex topics: Nanoparticle-Based Drug Delivery · Characterization and Applications of Magnetic Nanoparticles · Microfluidic and Bio-sensing Technologies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Multi‐Scale Robotics Lab Institute of Robotics and Intelligent Systems ETH Zürich, Tannenstrasse 3 Zürich CH‐8092 Switzerland

Departamento de Ciencias Campus de Arrosadía Universidad Pública de Navarra Pamplona 31006 Spain

Institute for Advanced Materials and Mathematics (INAMAT^{2}) Universidad Pública de Navarra Pamplona E‐31006 Spain

Departament de Ciència dels Materials i Química Física Institut de Química Teòrica i Computacional University of Barcelona Martí i Franquès, 1 Barcelona 08028 Spain

Institució Catalana de Recerca i Estudis Avançats (ICREA) Pg. Lluís Companys 23 Barcelona 08010 Spain

Department of Inorganic and Organic Chemistry Inorganic Chemistry Section University of Barcelona Carrer de Martí i Franquès, 1‐11 Barcelona 08028 Spain

Institute of Nanoscience and Nanotechnology (IN2UB) University of Barcelona Carrer de Martí i Franquès, 1‐11 Barcelona 08028 Spain

International Institute of Intelligent Nanorobots and Nanosystems College of Intelligent Robotics and Advanced Manufacturing State Key Laboratory of Photovoltaic Science and Technology Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception Institute of Optoelectronics Fudan University Shanghai 200433 China

Zhejiang Key Laboratory of Extreme Environment Functional Materials Yiwu Research Institute of Fudan University Yiwu 322000 China

Funding

National Natural Science Foundation of China · Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung · Generalitat de Catalunya

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