Covalent Organic Framework Barriers Implanted Nanomotors Propelled by Amplified Thermal Gradients

Abstract Covalent organic frameworks (COFs) regulated by molecular engineering are successfully employed as “thermal barriers” to construct motion‐enhanced photothermal nanomotors, realizing the direct experimental observation of steep asymmetric thermal gradients and precise motion regulation. The COF thermal barriers, strategically implanted between a spherical SiO ₂ core and an Au hemispherical shell, effectively inhibit the isotropic diffusion of photothermal energy from the asymmetric Au shell, resulting in a 4‐fold amplification of the local thermal gradient. The step thermal gradient achieved a steep 320% increase in motion speed compared to nanomotors without thermal barriers, with the remarkable highest speed up to ≈88 µm s ⁻¹ . Benefiting from the amplified thermal gradient, the asymmetric thermal field generated by COF barriers is directly observed experimentally using high‐resolution photothermal microscopy. Notably, the thermal conductivity of COFs can be precisely modulated through pore engineering, enabling accurate control of nanomotor speed at the molecular level. Leveraging the robust drug‐loading capacity of COF, motion‐enhanced COF nanomotors exhibit exceptional tissue penetration and drug delivery performance. Overall, the COF thermal barriers combine designable drug‐loading pore structure with tailored thermal conductivity properties, endowing the nanomotors with potent synergistic therapeutic effects for venous thrombosis via enhanced local photothermal ablation and heat‐triggered drug delivery.